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Abstract

In Vivo Administration of Cerebrospinal Fluid of Patients with Multiple Sclerosis; A New Model to Study Adult Neurogenesis in Different Stages of Disease

Multiple sclerosis (MS) is an autoimmune and demyelinating disease, affecting the central nervous system causing a wide spectrum of signs and symptoms. In adult mammalian brain, neural progenitor cells (NPCs) are placed in the subventricular zone of ventricles, subgranular zone of the dentate gyrus and give rise to new cells. In addition, alterations in adult neurogenesis are implicated in psychiatric disease in humans. Currently, there is no satisfactory evidence to describe how neurogenesis changes during pathogenesis of MS disease. It can be because of the lack of suitable animal model that represents pathogenesis of different stages of MS disease. Given that, cerebrospinal fluid (CSF) as a mirror can reflects major part of pathological conditions of disease in vivo administration of CSF derived from patients in to the brain ventricles of mice can lead to an experimental animal model for studying neurogenesis and other pathophysiology of multiple sclerosis. This strategy will help researchers to unravel the mechanisms in which neurogenesis changes in different stages of MS disease.


Author(s):

Meysam Yazdankhah and Somayeh Ebrahimi-Barough



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