Gliomatosis Cerebri Mimicking Viral Encephalitis – A Case Report

We present a case of a patient with a radiological diagnosis of gliomatosis cerebri whose clinical presentation mimicked that of viral encephalitis. A 69-year-old female presented with a few days history of confusion, headache and fever. Examination revealed mild extensor weakness in the left upper and lower limb. CSF showed a mild pleocytosis; gram stain, bacterial and viral cultures as well as HSV PCR were negative. CT brain showed diffuse right hemispheric oedema with a focal enhancement in the temporal lobe, which was also demonstrated on MRI brain. Aciclovir and dexamethasone were started for presumed viral encephalitis. After 8 days of treatment, the patient's symptoms improved and she was discharged. One week later, the patient was more confused with new left sided hemianopia. Repeat MRI brain revealed progression of the diffuse right-sided oedema, extending into the corpus callosum and cerebellum. Following discussion with a specialist neurooncology centre, we were advised that the images were indicative of extensive Gliomatosis Cerebri. Unfortunately, the patient died of pneumonia before tissue diagnosis was obtained. GC is a rare form of infiltrative glioma involving three or more lobes of the CNS. It has a varying clinical presentation and there are frequent case reports of GC mimicking alternative diagnoses. GC has been reported to mimic viral encephalitis in only one previous adult case.


Georgia Whitlow*, Mohamed Saleh and Saeedur Rahman

Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Google scholar citation report
Citations : 563

Journal of Neurology and Neuroscience received 563 citations as per google scholar report

Abstracted/Indexed in
  • Google Scholar
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor
  • Secret Search Engine Labs
  • Euro Pub

View More »

Flyer image


rolex replica