Normative Data of the Corpus Callosum Index and Discriminant Validity in Patients with Multiple Sclerosis

Background: The corpus callosum (CC) plays an important role in many cognitive and behavior functions and can be easily identified by conventional Magnetic Resonance Imaging (MRI). For these reasons, its integrity has been used as predictor of symptoms in different pathologies.

Methods and findings: to provide standardized data of the corpus callosum index (CCI) and obtain a cut-off point as a possible early marker of cognitive impairment in multiple sclerosis (MS), 209 healthy subjects and 96 patients were consecutively evaluated with a brain MRI scanning protocol. CCI was measured by two blinded raters. ROC curves were obtained for the total of sample and subgroups and the Youden Index was calculated to indentify the best cut-off points.

Results: Normative data of CCI are presented by age. No sex differences were found. Cut-off points were established for subjects in different age groups.


María Yaiza Pérez-Martín, Montserrat González-Platas, Alejandro Jiménez-Sosa, Julio PlataBello, Arelys López-Segura and Elisa Lucas-Hernández

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