Non-Invasive Method to Diagnose the Liver Fibrosis by Using Electrospinography

The liver is stimulated by both sympathetic and the parasympathetic nerve systems (Autonomic nervous system ANS). These nerves are consequent from the splanchnic and vagal nerves that surround the portal vein and hepatic artery. The afferent signals which responsible for glucose level, osmolality and lipid level is delivered from portal vein to Central nervous system (CNS). In other hand the efferent signals came from CNS to liver by using sympathetic nerves to control in liver functions. The IP injection of carbon tetrachloride CCl₄ make a hepatotoxicity for liver cell and this variation will be detected by afferent nerves to CNS. This will make CNS sent efferent signal different from the normal one. The efferent signals from the surface of spinal cord were recorded by using Electrospinogram device, which measure the potential difference for a specific segment which specify liver innervation (T7-T12). Then these signals were used to diagnose changes in liver functions which result in diagnosis liver diseases in non-invasive method by using only two electrodes on the skin surface of specific segment on spinal cord.

Author(s):

Ahmed A Hassan*, Amina Omar and El-Sayed M El-Sayed

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