Intracranial Primary Castleman Disease: Case Report

Castleman disease is a rare lymphoproliferative disorder. Its etiology is unknown and its course is usually benign. It is secondary to an irregular growth of lymphatic tissue and it can exhibit two forms: a localized and a disseminated or multi-centric. Histopathological there are three forms: hyaline vascular, plasma cell and mixed or transitional, when meninges are affected. When the affection is meningeal is mimics a meningioma. We reported a rare case of 38 years old woman which developed seizures, the MRI shoed a cerebral tumor that was diagnosed as meningioma. Tumoral exegesis was performed; histologically it was characterized by a dense lymphocytic infiltrate with abundant lymphoblasts and plasma cells forming germinal centers. The vessels showed lymphoblast proliferation, with hyalinized stroma. For immunohistochemistry a large number of lymphoblasts observed were also positive. We report the first case of this rare disease in our institution, an injury that was confused and treated as meningioma.

Author(s):

Martha Lilia TS*, Katiuska C, Carlos-Sánchez G and Citlaltépetl Salinas L

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