Intracranial Primary Castleman Disease: Case Report

Castleman disease is a rare lymphoproliferative disorder. Its etiology is unknown and its course is usually benign. It is secondary to an irregular growth of lymphatic tissue and it can exhibit two forms: a localized and a disseminated or multi-centric. Histopathological there are three forms: hyaline vascular, plasma cell and mixed or transitional, when meninges are affected. When the affection is meningeal is mimics a meningioma. We reported a rare case of 38 years old woman which developed seizures, the MRI shoed a cerebral tumor that was diagnosed as meningioma. Tumoral exegesis was performed; histologically it was characterized by a dense lymphocytic infiltrate with abundant lymphoblasts and plasma cells forming germinal centers. The vessels showed lymphoblast proliferation, with hyalinized stroma. For immunohistochemistry a large number of lymphoblasts observed were also positive. We report the first case of this rare disease in our institution, an injury that was confused and treated as meningioma.


Martha Lilia TS*, Katiuska C, Carlos-Sánchez G and Citlaltépetl Salinas L

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