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Alzheimer's Disease and Diabetes: Diffusion Tensor Imaging as a Probable Diagnostic Measure

The main neuropathological features of Alzheimer’s disease, a chronic neurodegenerative condition, are amyloid plaques (extracellular lesions) and neurofibrillary tangles (intercellular lesions) agglomeration in brain tissue. Some studies illustrate that Diabetes Mellitus type II might facilitate accumulation of amyloid-beta in brain tissue; can dispose patients to Alzheimer’s disease. In brain, water molecules mainly diffuse in the same directions as the neural pathways; amyloid-beta depositions as obstacles alter the normal directions of water motion in brain tissue ergo presenting as abnormalities in images taken by Diffusion Tensor Imaging that can be utilized for early diagnosis of Alzheimer’s disease.


Arshia Zarduei, Bahar Pourmennati and Asma Darvishi

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