Quick Opium Detoxification With 100 mg of Buprenorphine
Jamshid Ahmadi* and Bahare Oji
Substance Abuse Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
- *Corresponding Author:
- Jamshid Ahmadi
Founder and Director
Substance Abuse Research Center
Shiraz University of Medical Sciences
Tel: +98-71-3627 93 19
Received date: May 18, 2016; Accepted date: Sep 30, 2016; Published date: Oct 03, 2016
Citation: Ahmadi J, Oji B. Quick Opium Detoxification With 100 mg of Buprenorphine. J Neurol Neurosci. 2016, 7:5. doi:10.21767/2171-6625.1000149
Background: Dependency to opium is a worldwide problem. Objective: To merit the competency of a single high dose of buprenorphine in opium detoxification.
Results: Administration of 100 mg of buprenorphine as a single dose is very effective in the opium detoxification.
Discussion: Our study suggests that administration of 100 mg of sublingual buprenorphine as a high single dose is quite practical in opium detoxification. Hence, this experience could be a factual addition to the literature.
Conclusions: We infer that a single high dose of buprenorphine efficaciously treats opium withdrawal symptoms.
Buprenorphine; Single high dose; Opium
FDA (Food and Drug Administration) endorsed
buprenorphine which is a partial mu agonist for opioids
Buprenorphine is a safe drug with less chance of toxicity and
In opioid detoxification, buprenorphine is more helpful than
methadone [2-4]. Research studies indicated that 8 mg of
buprenorphine is comparable to 60 mg of methadone
considering retention rates and opioids negative urines .
Investigators narrated that buprenorphine can lower the
incidence of HIV and other allied disorders following opioids
It is a long time that people have been using up opium for
different purposes. For example in Asia opium had been used
for delectation, or for the treatment of pain, diarrhea and
premature ejaculation [8-10].
Many reports and research studies denote that physical and
mental disorders are lifting universally [11-29]. In psychiatric
disorders, substance joined disorders have been appeared as
boosting quandary and have resulted more presentations to
emergency departments, outpatient and inpatient psychiatric
In this study we are hinting a single high dose of 100 mg of
buprenorphine for prompt opium detoxification.
We could not find substantial experiences on this subject, so
this study may add to the literature.
Quick opioids detoxification with a single high dose of
buprenorphine is a novel approach. Now we are going to
describe opium detoxification of a patient who dramatically
answered to a single high dose of 100 mg of buprenorphine.
Our patient was a married, 46-year-old self-employed with
secondary school education. BE lived with his family in Eghlid
city of Fars province in south region of Iran.
BE began smoking tobacco and opium since 15 years prior
to this admission. He stepwise increased the dose of opium
and became heavy opium dependent. BE bit by bit developed,
hyper talkativeness, anxiety, insomnia, irritability,
hopelessness and depression. Since 6 months prior to
hospitalization his symptoms were worsened.
Two years prior to the current hospitalization, he was
admitted in this hospital with the above mentioned symptoms.
Due to agitation, headache, paranoid ideas, hyper
talkativeness, depression and somatization he was admitted in
During detailed psychiatric interview and exact mental
status examination he was very restless, agitated, hyper
talkative, irritable, paranoid and depressed. In meticulous
physical and neurological examinations, we could not find any
Urine drug screening tests were positive for methadone and
benzodiazepines. Tests of serology for viral markers (HIV, HCV
and HB Ag) were normal.
With reference to comprehensive medical, psychiatric, and
substance use history, BE was diagnosed as “opioid induced
depressive disorder with severe use disorder.
In hospital admission, he received paroxetine 20 mg/d for
the treatment of depression, chlorpromazine 500 mg/d for the
treatment of severe agitation and insomnia. He also received
clonidine 0.2 mg, baclofen 50 mg and ibuprofen 1200 mg per
day for the treatment of opium withdrawal symptoms.
We should emphasize that the Food and Drug
Administration (FDA) recommended clonidine for the
reduction of hypertension, baclofen for the treatment of
spasticity, and non-steroidal anti-inflammatory drugs (NSAIDS)
such as ibuprofen for the reduction of pain, inflammation, and
In the 8th day of admission he complained of severe
withdrawal pain and craving, so we administered 100 mg of
sublingual buprenorphine only as a single high dose.
According to the close monitoring, exact measurement and
detailed interview (3 times a day) for opium withdrawal pain
and craving, BE reported a considerable reducing level of pain
and craving after receiving of a single dose of 100 mg of
At the end and after treatment of opium withdrawals, BE
also received 6 sessions of electro convulsive therapy for the
treatment of severe and resistant somatization and depressive
BE was discharged without any withdrawal symptoms of
opium and also any psychiatric symptoms after 4 weeks of
Nowadays, Iranian opioid dependents are commonly
detoxified or treated with methadone, buprenorphine or
Our study indicates that administration of 100 mg of
sublingual buprenorphine as a high single dose is quite
applicable in the treatment of opium withdrawal symptoms.
So, this study could be a factual addition to the literature.
We infer that a single high dose of 100 mg of sublingual
buprenorphine efficaciously treat opium withdrawal
Overall, 100 mg of buprenorphine as a single high dose is
more effective than sudden cessation or little by little stepdown
in the opium dosage.
None to be declared.
Conflict of Interests
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