Functional Proteomics is a useful technology to study the neuronal biochimism, allowing to evaluate the metabolic changes within neuronal cells and brain tissue that may imply some physiopathological modifications. In fact, changes in brain energy metabolism was shown to be causative of development/progression of both neurological and psychiatric disorders. In this paper, it is particularly described the role of brain energy metabolism as a key etiopathological factor in dementias, in the perspective of using functional Proteomics as a tool for novel biomarker discovery.
Villa Roberto Federico and Ferrari Federica
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