Abstract

4-Hydroxybenzyl Alcohol Prevents Epileptogenesis As Well As Neuronal Damage in Amygdaloid Kindled Seizures

Background: 4-Hydroxybenzyl alcohol (4-HBA), one of the major active phenolic constituents of Gastrodia elata Blume, has been shown to be a neuroprotective agent. Previous studies have demonstrated the anticonvulsive effect of Gastrodia elata, while no studies have investigated the antiepileptogenic effect of 4-HBA.

Methods: We examined the effect of 4-HBA (25 mg/kg, 50 mg/kg or 100 mg/kg i.p.) on amygdaloid kindled seizures. Fully kindled seizures were achieved by daily electrical stimulation of the amygdala. Seizure stage and afterdischarge duration (ADD) were assessed daily. The effects of 4-HBA on neuronal loss were observed before kindling and 20 days after kindling by Nissl staining.

Results: We found that treatment with 50 mg/kg 4-HBA delayed seizure stage progression, and 25 mg/kg and 50 mg/kg 4-HBA shortened the corresponding ADD. Rats pretreated with 50 mg/kg 4-HBA needed more kindling stimulations to reach stages 4-5 and exhibited more cumulative ADD to stage 5. Pretreatment with 50 mg/kg 4-HBA shortened the number of days in stages 4–5 and decreased the incidence of generalized seizures. Pretreatment with 4-HBA showed no effect on fully kindled rats. Moreover, 50 mg/kg 4-HBA attenuated neuronal loss in the ipsilateral CA1 and the bilateral entorhinal cortex.

Conclusion: Our data suggests that 4-HBA can protect against epileptogenesis by preventing the after-discharge propagation in amygdaloid kindled seizures. In addition, the anti-epileptogenic activity may be related to the neuroprotective function of 4-HBA in the late stage of kindling.


Author(s):

Yi Guo, Yi Su, Chun-Hong Shen, Yi Yang, Yao Ding and Mei-Ping Ding



Abstract | Full-Text | PDF

Share this  Facebook  Twitter  LinkedIn  Google+

Recommended Conferences

  • 2nd International Conference on Pediatric Neurology
    August 31-September 01, 2017 Prague, Czech Republic
  • 15th European Neurology Congress
    August 29-31, 2017 London, UK
Flyer image

Abstracted/Indexed in

  • Google Scholar
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Proquest Summons
  • SciLit - Scientific Literature